Giant cell tumor bone pdf files

Looking for medication to treat giant cell tumor of bone. Most often, the tumors develop at the lower end of the femur thighbone or upper end of the tibia shinbone, close to the knee joint. After a wide resection, no recurrences were reported after 39 months of follow. Giant cell tumors are usually found in the long bones, most often the distal femur, proximal tibia, and distal radius. Radiation therapy for giant cell tumors of bone request pdf. Giant cell tumor accounts for 5 to 9 percent of all primary bony tumors. Giant cell tumor of bone is a locally aggressive neoplasm that represents 5% of all primary bone tumors and has a predilection for long bones and vertebrae of young adults.

Giant cell tumor of the fourth metacarpal bone showing permeative growth pattern. Giantcell tumor of bone gctb is a rare tumor typically affecting the bones of skeletally mature young adults, with peak incidence in the third and fourth decades of life. Giant cell tumor is a one of the most common primary bone lesions in the distal phalanx. Although rarely lethal, benign bone tumors may be associated with a substantial disturbance of the local bony architecture that can be particularly troublesome in periarticular locations. Giant cell tumour of bone gct is a benign noncancerous tumour which can develop in the bones of the body. Giant cell tumor gct of bone is a locally aggressive benign neoplasm that is associated with a large biological spectrum ranging from latent benign to highly recurrent and occasionally. Giant cell tumor of bone is a benign tumor with an aggressive behavior. For those not suitable for surgery, therapeutic radiotherapy rt is one classic modality. Compare current giant cell tumor of bone drugs and. Find a list of current medications, their possible side effects, dosage, and efficacy when used to treat or reduce the symptoms of giant. Matrix metalloproteinase 9 gelatinase b is expressed in multinucleated giant cells of human giant cell tumor of bone and is associated with vascular invasion.

Giant cell tumor of the bone gctb is a benign but locally aggressive tumor. It can occur in any bone and can incur significant morbidity, due to a tendency to occur in the bones surrounding the wrist and knee, as well as the axial skeleton. Ueda y, imai k, tsuchiya h, fujimoto n, nakanishi i, katsuda s, et al. Pdf giant cell tumor of bone revisited researchgate. A giant cell tumor of bone is a type of benign noncancerous tumor that grows at the ends of the bodys long bones. Its typical subarticular location and high recurrence risk can be associated with significant morbidity. Giant cell tumor of the bones of the hand and foot. Giant cell tumor of the spine gcts accounts for 36 % of gctb.